Melaxen

MELAXEN® contains melatonin, a hormone secreted by the pineal gland in a 24-hour circadian rhythm, regulating the normal sleep/wake cycle. Increased secretion of melatonin naturally occurs during the hours after dark. It has been reported that adults experience a 37% decline in daily melatonin output between 20-70 years of age. Melatonin helps to support healthy sleep cycles in individuals suffering from occasional sleeplessness, particularly when adjusting to staggered work cycles or jet lag.




Recommended Intake:
Take 1-2 tablets 30-40 minutes before sleep with juice or water.

Formulated for:
Adults over 18 years old.

General Information:
Vitamins and minerals are chemical substances that are vital to the maintenance of normal body functions. Most people obtain enough vitamins and minerals in their diet, but some people have vitamin deficiencies. Vitamin and mineral products should not be regarded as a substitute for a varied diet.

Pharmotherapeutic Group & Information:
Melatonin is a hormone secreted from the pineal gland in a 24 hour circadian rhythm, regulating the normal sleep/wake cycle. Increased secretion occurs during dark hours. Adults experience a 37% decline in daily melatonin output between 20-70 years of age. Melatonin helps to support healthy sleep cycles in individuals suffering from occasional sleeplessness, particularly when adjusting to shift-work cycles or jet lag.

Contraindications:
This drug is contraindicated in the case of history of allergy to any of the ingredients. The use of this drug is inadvisable during pregnancy or when nursing.

Warnings:
Excessive dosages may cause morning sedation or drowsiness. This product is not to be used by persons under 18 years of age. Keep out of sight and reach of children. As with any vitamin and mineral product, if you are taking medication, consult your doctor before use. In case of accidental overdose, call a doctor or poison control center immediately.

Special Warnings:
Because no data are available, the use of this drug by pregnant women or nursing mothers is unadvisable.
Central nervous system: Drowsiness, dysphoria (especially in depressed patients), giddiness
Gastrointestinal: Nausea

Interactions:
Drugs that deplete vitamin B6 may inhibit the body's ability to synthesize melatonin from the tryptophan-serotonin-melatonin pathway. These include oral contraceptives, estrogen, fluvoxamine, hydralazine, loop diuretics, penicillamine, and theophylline. In addition, beta-blockers and benzodiazepines may deplete melatonin by enzyme inhibition. Isoniazid alters vitamin B6 metabolism, limiting formation of melatonin. Theoretically, effects may be additive with medications which cause CNS sedation. A deficiency of pyridoxine inhibits the synthesis of melatonin.
 




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